N.m.r. study of the hydration of pyruvic acid
Abstract
The ratio of the concentration of pyruvic acid to that of its hydrate (2,2-dihydroxypropanoic acid) has been determined from the ratio of the intensities of their methyl resonances at 60 Mc/sec. The kinetics of the hydration of pyruvic acid have been studied; the hydrogen-ion-dependent rate constant of the hydration is 5.6 l. mole–1 sec–1, and that of the dehydration 8.7 l. mole–1 sec–1. The results generally confirm the conclusions dawn from a limited study of these phenomena at 28 Mc/sec.