Issue 0, 1967

Amino-acids and peptides. Part XXVI. The use of 1-piperidyl esters in peptide synthesis: further studies

Abstract

Further examples of the use of 1-piperidyl esters for the synthesis of protected dipeptides have given good yields of pure product except when two valine residues were involved (in which case the reaction of the analogous p-nitrophenyl ester was also very slow), or when one residue was α-aminoisobutyric acid. The reactions of benzyloxy-carbonylamino-acid 1-piperidyl esters with the methyl esters of L-leucyl-L-leucylglycine, L-phenylalanyl-L-leucylglycine, and L-valyl-L-eucylglycine proceeded more slowly than with α-amino-esters but satisfactory yields were obtained except in one case, again involving valine.

Article information

Article type
Paper

J. Chem. Soc. C, 1967, 2371-2374

Amino-acids and peptides. Part XXVI. The use of 1-piperidyl esters in peptide synthesis: further studies

J. H. Jones, B. Liberek and G. T. Young, J. Chem. Soc. C, 1967, 2371 DOI: 10.1039/J39670002371

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