Synthesis of 2,3-disubstituted chromones: cyclisation of the enolesters of o-acyloxyphenyl alkyl ketones
Abstract
2,3-Disubstituted chromones have been synthesised by the cyclisation under basic conditions of the enol esters of o-acyloxyphenyl alkyl ketones. A mechanism involving an intramolecular electrophilic addition between the enol double bond and the o-acyl group is suggested. Phenyl and enol esters, and chromones have been prepared.