SCHEDULED MAINTENANCE
Carboxylic esters react with phosphorus pentachloride and thionyl chloride to give the corresponding acyl chlorides. It has been demonstrated by examining the fate of the oxygen-18 label in the esters C6H5·CO18OCH2·C6H5 and p-CH3·OC6H4·CO18OCH2·C6H5, that reaction with phosphorus pentachloride and thionyl chloride involves initial nucleophilic attack by the carbonyl-oxygen atom.
M. Green and D. M. Thorp, J. Chem. Soc. B, 1967, 1067 DOI: 10.1039/J29670001067
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