An electric moment study of 6-chloro-9-ethylpurine, 6-chloro-9-phenethylpurine, and 6-chloro-9-phenylpurine

Abstract

The dipole moments of 6-chloro-9-ethylpurine and 6-chloro-9-phenethylpurine, in carbon tetrachloride, are 4·75 ± 0·02 D and 4·66 ± 0·02 D, respectively, and that of 6-chloro-9-phenylpurine is 4·75 ± 0·02 D. The inactivity of 6-chloro-9-phenylpurine as an antimetabolite, in contrast to the activity of the other two derivatives, cannot be explained on the basis of the electric moments.