Issue 1093, 1967

The spectrophotometric determination of Ampicillin

Abstract

A method is described for the determination of Ampicillin (α-amino-benzyl penicillin) based on the spectrophotometric measurement at 320 mµ of a compound formed by acid degradation of the penicillin at 75° C in the presence of buffer solution at pH 5·2 and a trace of a copper salt. Results obtained on samples of Ampicillin, Ampicillin Trihydrate and Ampicillin Sodium show good agreement with those recorded by the cup-plate microbiological method.

Article information

Article type
Paper

Analyst, 1967,92, 247-252

The spectrophotometric determination of Ampicillin

J. W. G. Smith, G. E. de Grey and V. J. Patel, Analyst, 1967, 92, 247 DOI: 10.1039/AN9679200247

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