The electrophilic substitution of 6-methylpyrrolo[2,1-b]thiazole has been studied quantitatively. Acetylation, formylation, trifluoroacetylation, and nitrosation occur exclusively at position 5. Further reaction gives 5,7-disubstitution products. Tritylation gives mainly 5,7-ditrityl- and 5-trityl- together with some 7-trityl-6-methyl-pyrrolo[2,1-b]thiazole.
S. McKenzie, B. B. Molloy and D. H. Reid, J. Chem. Soc. C, 1966, 1908 DOI: 10.1039/J39660001908
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