Some branched-chain analogues of analgesically active 1-(2-aminoethyl)-2-benzylbenzimidazole derivatives

Abstract

The synthesis of some 1-(2-aminopropyl)-2-benzyl(and 4-ethoxybenzyl)benzimidazoles is reported. A p.m.r. study of the alkylation of 2-benzylbenzimidazole with 2-chloro-1-dimethylaminopropane shows that reactions of this type represent a practicable route to 1-(2-aminopropyl)benzimidazoles, since the 1-(2-amino-1-methylethyl)-isomer forms only a small percentage of the reaction product.