The isolation of water-soluble natural products – challenges, strategies and perspectives

Roberto G. S. Berlinck, Camila M. Crnkovic, Juliana R. Gubiani, Darlon I. Bernardi, Laura P. Ióca and Jairo I. Quintana-Bulla

Nat. Prod. Rep., 2022, 39, 596
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Expanstines A–D: four unusual isoprenoid epoxycyclohexenones generated byPenicillium expansumYJ-15 fermentation and photopromotion

Jia-Peng Wang, Yan Shu, Shi-Xi Liu, Jun-Tao Hu, Cheng-Tong Sun, Hao Zhou, Dong Gan, Xue-Yun Cai, Wei Pu, Le Cai and Zhong-Tao Ding

Org. Chem. Front., 2019, 6, 3839
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The chemistry and biology of guanidine secondary metabolites

Roberto G. S. Berlinck, Darlon I. Bernardi, Taicia Fill, Alessandra A. G. Fernandes and Igor D. Jurberg

Nat. Prod. Rep., 2021, 38, 586
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Feature-Based Molecular Networking Discovery of Bromopyrrole Alkaloids from the Marine Sponge Agelas dispar

Vítor F. Freire, Juliana R. Gubiani, Tara M. Spencer, Eduardo Hajdu, Antonio G. Ferreira, Dayana A. S. Ferreira, Erica V. de Castro Levatti, Joanna E. Burdette, Carlos Henrique Camargo, Andre G. Tempone and Roberto G. S. Berlinck

J. Nat. Prod., 2022, 85, 1340
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High-throughput protein crystallography to empower natural product-based drug discovery

Raphael Meneghello, Joane K. Rustiguel, Evandro Ares de Araújo, Rafael de Felício, Arthur Zanetti N. Fernandes, Everton L. F. Ferreira, Juliana R. Gubiani, Agnes A. S. Takeda, Amanda Araujo, Caio C. de Lima Silva, Ariane F. Bertonha, Raquel P. M. Urano, Daniel M. Trindade, Thiago M. Cunha, Alisson C. Cardoso, Roberto G. S. Berlinck, Andrey F. Ziem Nascimento and Daniela B. B. Trivella

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Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy

InWha Park, Goeun Park, Yoojin Choi, Seung-Woo Jo, Hak Cheol Kwon, Jin-Soo Park and Jin Wook Cha

Antioxidants, 2022, 11, 2206
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Target identification and validation of natural products with label-free methodology: A critical review from 2005 to 2020

Lingyun Dai, Zhijie Li, Dan Chen, Lin Jia, Jinan Guo, Tianyun Zhao and Pär Nordlund

Pharmacology & Therapeutics, 2020, 216, 107690
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The EI‐MS Fragmentation Mechanisms of the Bacterial Diterpenes Polytrichastrene A and Wanju‐2,5‐diene

Anwei Hou and Jeroen S. Dickschat

Eur J Org Chem, 2021, 2021, 6417
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Natural products in drug discovery: advances and opportunities

Atanas G. Atanasov, Sergey B. Zotchev, Verena M. Dirsch, Ilkay Erdogan Orhan, Maciej Banach, Judith M. Rollinger, Davide Barreca, Wolfram Weckwerth, Rudolf Bauer, Edward A. Bayer, Muhammed Majeed, Anupam Bishayee, Valery Bochkov, Günther K. Bonn, Nady Braidy, Franz Bucar, Alejandro Cifuentes, Grazia D’Onofrio, Michael Bodkin, Marc Diederich, Albena T. Dinkova-Kostova, Thomas Efferth, Khalid El Bairi, Nicolas Arkells, Tai-Ping Fan, Bernd L. Fiebich, Michael Freissmuth, Milen I. Georgiev, Simon Gibbons, Keith M. Godfrey, Christian W. Gruber, Jag Heer, Lukas A. Huber, Elena Ibanez, Anake Kijjoa, Anna K. Kiss, Aiping Lu, Francisco A. Macias, Mark J. S. Miller, Andrei Mocan, Rolf Müller, Ferdinando Nicoletti, George Perry, Valeria Pittalà, Luca Rastrelli, Michael Ristow, Gian Luigi Russo, Ana Sanches Silva, Daniela Schuster, Helen Sheridan, Krystyna Skalicka-Woźniak, Leandros Skaltsounis, Eduardo Sobarzo-Sánchez, David S. Bredt, Hermann Stuppner, Antoni Sureda, Nikolay T. Tzvetkov, Rosa Anna Vacca, Bharat B. Aggarwal, Maurizio Battino, Francesca Giampieri, Michael Wink, Jean-Luc Wolfender, Jianbo Xiao, Andy Wai Kan Yeung, Gérard Lizard, Michael A. Popp, Michael Heinrich, Ioana Berindan-Neagoe, Marc Stadler, Maria Daglia, Robert Verpoorte and Claudiu T. Supuran

Nat Rev Drug Discov, 2021, 20, 200
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Water-Soluble Glutamic Acid Derivatives Produced in Culture byPenicillium solitumIS1-A from King George Island, Maritime Antarctica

Julie P. G. Rodríguez, Darlon I. Bernardi, Juliana R. Gubiani, Juliana Magalhães de Oliveira, Raquel P. Morais-Urano, Ariane F. Bertonha, Karin F. Bandeira, Jairo I. Q. Bulla, Lara D. Sette, Antonio G. Ferreira, João M. Batista, Thayná de Souza Silva, Raquel Alves dos Santos, Carlos H. G. Martins, Simone P. Lira, Marcos G. da Cunha, Daniela B. B. Trivella, Nathalia Grazzia, Natália E. S. Gomes, Fernanda Gadelha, Danilo C. Miguel, Ana Carolina G. Cauz, Marcelo Brocchi and Roberto G. S. Berlinck

J. Nat. Prod., 2020, 83, 55
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Chemical cues for intraspecific chemical communication and interspecific interactions in aquatic environments: applications for fisheries and aquaculture

Michiya Kamio, Hidenobu Yambe and Nobuhiro Fusetani

Fish Sci, 2022, 88, 203
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New drug discovery and development from natural products: Advances and strategies

Yixin Wang, Fan Wang, Wenxiu Liu, Yifei Geng, Yahong Shi, Yu Tian, Bin Zhang, Yun Luo and Xiaobo Sun

Pharmacology & Therapeutics, 2024, 264, 108752
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NP3 MS Workflow: An Open-Source Software System to Empower Natural Product-Based Drug Discovery Using Untargeted Metabolomics

Cristina F. Bazzano, Rafael de Felicio, Luiz Fernando Giolo Alves, Jonas Henrique Costa, Raquel Ortega, Bruna Domingues Vieira, Raquel Peres Morais-Urano, Luciana Costa Furtado, Everton L. F. Ferreira, Juliana R. Gubiani, Roberto G. S. Berlinck, Leticia V. Costa-Lotufo, Guilherme P. Telles and Daniela B. B. Trivella

Anal. Chem., 2024, 96, 7460
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A network pharmacology-based approach to understand the mechanism of action of anti-mycobacterial activity of Acacia nilotica: a modelling and experimental study

Madhumitha Suresh, Kadambari Vijay Sai, Kartik Mitra, Radhika Ravindran and Mukesh Doble

Mol Divers, 2025, 29, 2227
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Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of Pseudomonas aeruginosa PAO1

Yuanyuan Hu, Ge Liu, Chaomin Sun and Shimei Wu

Marine Drugs, 2024, 22, 233
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Simplified Synthesis of Poly(ethyleneimine)-Modified Silica Particles and Their Application in Oligosaccharide Isolation Methods

Xingyun Zhao, Yifan Niu, Chengxiao Zhao, Zhenyu Li, Ke Li and Xuemei Qin

IJMS, 2024, 25, 9465
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Testacosides A–D, glycoglycerolipids produced by Microbacterium testaceum isolated from Tedania brasiliensis

Jairo I. Quintana-Bulla, Luciane A. C. Tonon, Lamonielli F. Michaliski, Eduardo Hajdu, Antonio G. Ferreira and Roberto G. S. Berlinck

Appl Microbiol Biotechnol, 2024, 108
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Algae and Cyanobacteria Fatty Acids and Bioactive Metabolites: Natural Antifungal Alternative Against Fusarium sp.

Miguel E. López-Arellanes, Lizbeth Denisse López-Pacheco, Joel H. Elizondo-Luevano and Georgia María González-Meza

Microorganisms, 2025, 13, 439
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Modern Trends in Natural Antibiotic Discovery

Anna A. Baranova, Vera A. Alferova, Vladimir A. Korshun and Anton P. Tyurin

Life, 2023, 13, 1073
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Thesium chinense Turcz.: An ethnomedical, phytochemical and pharmacological review

Guo-Hui Li, Kai-Li Fang, Kang Yang, Xin-Ping Cheng, Xiao-Ning Wang, Tao Shen and Hong-Xiang Lou

Journal of Ethnopharmacology, 2021, 273, 113950
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