A GSH-consuming nanoamplifier for synergistic SO2 gas therapy and ferroptosis promotion

Fengqin Wang; Yan Miao; Jiawen Yang; Jian An; Yawen Xu; Yuxing Huang; Gehua Huang; Suxuan Ge; Yinfang Jiang; Yan Xue; Yan Cai; Jin Wang; Tingting Chen; Yong Yao; Yang Wang

doi:10.1039/D5CC05548B

A GSH-consuming nanoamplifier for synergistic SO₂ gas therapy and ferroptosis promotion

Fengqin Wang,†^a Yan Miao,†^b Jiawen Yang,^b Jian An,^b Yawen Xu,^b Yuxing Huang,^b Gehua Huang,^b Suxuan Ge,^b Yinfang Jiang,^a Yan Xue,*^c Yan Cai,^b Jin Wang,^b Tingting Chen,^b Yong Yao

*^b and Yang Wang

*^b

Author affiliations

* Corresponding authors

^a Nantong Institute of Technology, Nantong, Jiangsu 226006, China

^b School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019, China
E-mail: yaoyong1986@ntu.edu.cn, ywang85@ntu.edu.cn

^c Research Center of Molecular Medicine, Health College of Jiangsu Province, Nantong 226010, China
E-mail: bulb0415@163.com

Abstract

A hyaluronic acid-modified nanotheranostic platform (Fe-DALN@HA) was constructed via Fe³⁺-coordinated self-assembly of a GSH-responsive SO₂ prodrug, enabling tumor-targeted delivery and synergistic induction of gas-enhanced ferroptosis through SO₂ gas release and the Fenton reaction for effective cancer therapy.

This article is part of the themed collection: Chemical Communications HOT articles 2025

Chemical Communications

A GSH-consuming nanoamplifier for synergistic SO₂ gas therapy and ferroptosis promotion

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A GSH-consuming nanoamplifier for synergistic SO₂ gas therapy and ferroptosis promotion

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