Issue 39, 2024

Nanomaterial combined engineered bacteria for intelligent tumor immunotherapy

Abstract

Cancer remains the leading cause of human death worldwide. Compared to traditional therapies, tumor immunotherapy has received a lot of attention and research focus due to its potential to activate both innate and adaptive immunity, low toxicity to normal tissue, and long-term immune activity. However, its clinical effectiveness and large-scale application are limited due to the immunosuppression microenvironment, lack of spatiotemporal control, expensive cost, and long manufacturing time. Recently, nanomaterial combined engineered bacteria have emerged as a promising solution to the challenges of tumor immunotherapy, which offers spatiotemporal control, reversal of immunosuppression, and scalable production. Therefore, we summarize the latest research on nanomaterial-assisted engineered bacteria for precise tumor immunotherapies, including the cross-talk of nanomaterials and bacteria as well as their application in different immunotherapies. In addition, we further discuss the advantages and challenges of nanomaterial-engineered bacteria and their future prospects, inspiring more novel and intelligent tumor immunotherapy.

Graphical abstract: Nanomaterial combined engineered bacteria for intelligent tumor immunotherapy

Article information

Article type
Review Article
Submitted
05 Apr 2024
Accepted
09 Aug 2024
First published
14 Aug 2024

J. Mater. Chem. B, 2024,12, 9795-9820

Nanomaterial combined engineered bacteria for intelligent tumor immunotherapy

S. Qin, G. He and J. Yang, J. Mater. Chem. B, 2024, 12, 9795 DOI: 10.1039/D4TB00741G

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