Issue 14, 2022

A QCM study of strong carbohydrate–carbohydrate interactions of glycopolymers carrying mannosides on substrates

Abstract

Carbohydrates on cell surfaces are known to interact not only with lectins but also with other carbohydrates; the latter process is known as a carbohydrate–carbohydrate interaction. Such interactions are observed in complex oligosaccharides. It would be surprising if these interactions were observed in simple monosaccharides of mannose. In this study, the interaction between glycopolymers carrying monosaccharides of mannose was quantitatively investigated by quartz crystal microbalance measurements. We measured the interactions with glycopolymers carrying mannose, galactose and glucose. Surprisingly, the interaction between the glycopolymers and mannose was much stronger than that between other saccharides.

Graphical abstract: A QCM study of strong carbohydrate–carbohydrate interactions of glycopolymers carrying mannosides on substrates

Supplementary files

Article information

Article type
Paper
Submitted
25 Oct 2021
Accepted
02 Dec 2021
First published
08 Dec 2021

J. Mater. Chem. B, 2022,10, 2597-2601

A QCM study of strong carbohydrate–carbohydrate interactions of glycopolymers carrying mannosides on substrates

T. Oh, T. Uemura, M. Nagao, Y. Hoshino and Y. Miura, J. Mater. Chem. B, 2022, 10, 2597 DOI: 10.1039/D1TB02344F

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