Improved discrimination of phenylalanine enantiomers by surface enhanced Raman scattering assay: molecular insight into chiral interaction

Yanxiu He; Qinghai Zhou; Ning Wang; Haifeng Yang; Xinling Liu

doi:10.1039/D2AN00246A

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Improved discrimination of phenylalanine enantiomers by surface enhanced Raman scattering assay: molecular insight into chiral interaction†

Yanxiu He,‡^a Qinghai Zhou,

‡^a Ning Wang,^a Haifeng Yang

*^a and Xinling Liu

*^a

Author affiliations

* Corresponding authors

^a The Education Ministry Key Lab of Resource Chemistry, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China
E-mail: hfyang@shnu.edu.cn, xlliu@shnu.edu.cn

Abstract

SERS spectroscopy, a nontraditional chiral analysis tool, is used to discriminate between D- and L-phenylalanine (Phe), with the Raman scattering enhancement degree of D-Phe being 50-fold greater than that of L-Phe. Such discrimination is achieved by chiral interactions between Phe and the chiral drug molecule of sertraline on silver coated gold nanorods.

This article is part of the themed collection: 150th Anniversary Collection: Raman Spectroscopy and SERS

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Article information

DOI: https://doi.org/10.1039/D2AN00246A
Article type: Communication
Submitted: 10 Feb 2022
Accepted: 09 Mar 2022
First published: 10 Mar 2022

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Analyst, 2022,147, 1540-1543

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Improved discrimination of phenylalanine enantiomers by surface enhanced Raman scattering assay: molecular insight into chiral interaction

Y. He, Q. Zhou, N. Wang, H. Yang and X. Liu, Analyst, 2022, 147, 1540 DOI: 10.1039/D2AN00246A

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Improved discrimination of phenylalanine enantiomers by surface enhanced Raman scattering assay: molecular insight into chiral interaction†

Abstract

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