Issue 30, 2021

Calixarene-decorated liposomes for intracellular cargo delivery

Abstract

Amphiphilic calix[4]arenes, functionalized with guanidinium groups, are used to decorate the outer surface of liposomes and significantly improve the cellular uptake of a cargo compared to plain liposomes. The improved uptake is elicited and mediated by the interaction between the cationic polar heads of the macrocycle units embedded in the liposome bilayer and anionic heparan-sulfate proteoglycans surrounding the exterior of cells.

Graphical abstract: Calixarene-decorated liposomes for intracellular cargo delivery

Supplementary files

Article information

Article type
Communication
Submitted
31 May 2021
Accepted
28 Jun 2021
First published
16 Jul 2021
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2021,19, 6598-6602

Calixarene-decorated liposomes for intracellular cargo delivery

I. Morbioli, A. Casnati, J. D. Esko, Y. Tor and F. Sansone, Org. Biomol. Chem., 2021, 19, 6598 DOI: 10.1039/D1OB01055G

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