Issue 72, 2021

Ligand switchable site selectivity in C–H alkenylation of thiophenes by turnover-limiting step control

Abstract

The origin of switchable site selectivity during Pd-catalysed C–H alkenylation of heteroarenes has been examined through More O’Ferrall–Jencks, isotope effect, and DFT computational analyses, which indicate substitution of ionic thioether for pyridine dative ligands induces a change from selectivity-determining C–H cleavage to C–C bond formation, respectively.

Graphical abstract: Ligand switchable site selectivity in C–H alkenylation of thiophenes by turnover-limiting step control

Supplementary files

Article information

Article type
Communication
Submitted
28 Jun 2021
Accepted
10 Aug 2021
First published
10 Aug 2021

Chem. Commun., 2021,57, 9076-9079

Ligand switchable site selectivity in C–H alkenylation of thiophenes by turnover-limiting step control

R. Evans, J. Sampson, L. Wang, L. Lückemeier and B. P. Carrow, Chem. Commun., 2021, 57, 9076 DOI: 10.1039/D1CC03456A

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