Issue 1, 2014
From the journal:

Inorganic Chemistry Frontiers

Influence of an anti-metastatic ruthenium(iii) prodrug on extracellular protein–protein interactions: studies by bio-layer interferometry†

Aviva Levinaa  and  Peter A. Lay*a  

* Corresponding authors

a School of Chemistry, Room 307, F11, The University of Sydney, Sydney, NSW 2006, Australia
E-mail: peter.lay@sydney.edu.au
Fax: +61-2-93513329
Tel: +61-2-93514269

Abstract

In the first application of bio-layer interferometry in medicinal inorganic chemistry, Fe(III)–transferrin (Tf) binds strongly to Tf receptor 1 (TfR1), but an apo–Tf adduct of the anti-metastatic prodrug, NAMI-A does not bind specifically to TfR1. Binding of NAMI-A to albumin affects its interactions with other blood proteins, such as immunoglobulins.

Graphical abstract: Influence of an anti-metastatic ruthenium(iii) prodrug on extracellular protein–protein interactions: studies by bio-layer interferometry

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Article information

DOI
https://doi.org/10.1039/C3QI00054K
Article type
Communication
Submitted
27 Sep 2013
Accepted
14 Nov 2013
First published
16 Dec 2013
This article is Open Access
Creative Commons BY license

Inorg. Chem. Front., 2014,1, 44-48

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Influence of an anti-metastatic ruthenium(III) prodrug on extracellular protein–protein interactions: studies by bio-layer interferometry

A. Levina and P. A. Lay, Inorg. Chem. Front., 2014, 1, 44 DOI: 10.1039/C3QI00054K

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