In vivo        cell death mediated by synthetic ion channels

Bryan A. Smith; Megan M. Daschbach; Seth T. Gammon; Shuzhang Xiao; Sarah E. Chapman; Caroline Hudson; Mark Suckow; David Piwnica-Worms; George W. Gokel; W. Matthew Leevy

doi:10.1039/C1CC12933C

In vivo cell death mediated by synthetic ion channels†‡

Bryan A. Smith,^b Megan M. Daschbach,^d Seth T. Gammon,^a Shuzhang Xiao,^b Sarah E. Chapman,^b Caroline Hudson,^b Mark Suckow,^c David Piwnica-Worms,^a George W. Gokel*^d and W. Matthew Leevy*^b

Author affiliations

* Corresponding authors

^a Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, St. Louis, USA

^b Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, USA

^c Freimann Life Science Center, University of Notre Dame, Notre Dame, USA

^d Center for Nanoscience andDepartment of Chemistry and Biochemistry, University of Missouri St. Louis, One University Boulevard, St. Louis, USA
E-mail: gokelg@umsl.edu
Fax: +1 (314) 516-5342
Tel: +1-314-516-5321

Abstract

Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

This article is part of the themed collection: Supramolecular Chemistry

Chemical Communications

In vivo cell death mediated by synthetic ion channels†‡

Abstract

Supplementary files

Article information

Download Citation

Permissions

In vivo cell death mediated by synthetic ion channels

Social activity

Search articles by author

Spotlight

Advertisements