Issue 6, 2023
From the journal:

Analytical Methods

A ratiometric fluorescent dye for detection of Lys and Arg and its bioimaging in live cells and zebrafish larvae†

Tongxin Zhang,ab   Zhengfei Yang,c   Xiaoyan He,a   Luxin Guo,a   Jincheng Wang,a   Xuewen Jiang,*d   Ruling Shen*c  and  Xiuhong Lu ORCID logo *ab  

* Corresponding authors

a Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
E-mail: luxh@sumhs.edu.cn

b College of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China

c Shanghai Laboratory Animal Research Center, Shanghai 201203, China
E-mail: shenruling@slarc.org.com

d Department of Nuclear Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China
E-mail: jiangxuewen1976@126.com

Abstract

A ratiometric and pH-sensitive fluorescent dye named IDE was applied to the detection of argine and lysine from common amino acids and exploited to monitor the Lys and Arg levels in living cells and zebrafish larvae successfully. IDE will be a useful fluorescence indicator of pH changes by Lys and Arg.

Graphical abstract: A ratiometric fluorescent dye for detection of Lys and Arg and its bioimaging in live cells and zebrafish larvae

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Article information

DOI
https://doi.org/10.1039/D2AY01740G
Article type
Communication
Submitted
26 Oct 2022
Accepted
09 Jan 2023
First published
24 Jan 2023

Anal. Methods, 2023,15, 703-708

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A ratiometric fluorescent dye for detection of Lys and Arg and its bioimaging in live cells and zebrafish larvae

T. Zhang, Z. Yang, X. He, L. Guo, J. Wang, X. Jiang, R. Shen and X. Lu, Anal. Methods, 2023, 15, 703 DOI: 10.1039/D2AY01740G

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