Themed collection Journal of Materials Chemistry B HOT Papers

Nanoparticle-mediated surfactant therapy in patients with severe COVID-19.

Gas-generating nanoplatforms have promising therapeutic potential for cancer treatment.

The COVID-19 pandemic has led to an unprecedented global health challenge, creating sudden, massive demands for diagnostic testing, treatment, therapies, and vaccines.

This review summarizes the latest nanosystems with different functional nanomaterials that co-load and protect the siRNA/drugs, precisely target tumors, and release cargoes intelligently.

This review summarizes catalytic mechanisms, regulatory factors, measurement methods and various applications of SOD-like nanozymes, as well as proposes the current challenges and prospects in the development of SOD-like nanozymes.

This review introduces naturally-occurring saturated fatty acids (NSFAs) and their biomedical applications, including controlled drug release, targeted drug delivery, cancer therapy, antibacterial treatment, and tissue engineering.

Hyaluronic acid (HA) based hydrogels can be fabricated using various chemistries to study cancer cell behaviors in vitro.

This article reviews the use of two-dimensional materials as diagnostic platforms for the detection and sensing of the SARS-CoV-19 virus.

This review paper covers the recent progress of magnetic nanoparticles (MNP)-based gene delivery. Cutting-edge applications of MNP-based gene delivery on cancer therapy, neural repairing, regenerative medicine and gene editing are also introduced.

This review describes the recent progress in tissue adhesive hydrogel bioelectronics.

Nanoscale metal–organic frameworks (NMOFs) based on different metal ions for phototherapy.

Macrophages respond to physical stimuli of biomaterials, including stiffness, topography and confinement. Understanding the mechanical regulation of macrophage behaviour provides insights for biomaterial design.

Thermo-sensitive hydrogels based on different polymers have been broadly used in the pharmaceutical fields. In this review, the state-of-the-art thermo-sensitive hydrogels for drug delivery are elaborated

Multifunctional conductive hydrogels with representative preparation strategies and related properties.

This review summarizes the research works of non-enzymatic electrochemical sensors for the early diagnosis of Neurodegenerative disease.

This review highlights the recent development of mesoporous TiO₂-based architectures as promising sensing materials for diagnosing diseases and detecting harmful substances in the human body.

Deep eutectic solvents offer stimulating possibilities for biomolecular stabilization and manipulation, biocatalysis, bioextraction, biomass processing, and drug delivery and therapy.

The production of hydroxyapatite (HAP) composite coatings has continuously been investigated for bone tissue applications during the last few decades due to their significant bioactivity and osteoconductivity.

This review summarizes the recent advances in metal-ligand coordination nanomaterials-mediated synergistic radiotherapy with a emphasis focusing upon constructive strategies for radiosensitive nanoplatform and underlying synergistic mechanism.

Citrate-based mussel-inspired magnesium whitlockite composite adhesives were developed to augment bone-to-tendon healing, by providing interface adhesion, promoting bony inward growth from the bone tunnel, and enhancing chondrogenesis and osteogenesis of the bone–tendon interface.

Core–shell tecto dendrimers with improved core rigidity can be synthesized using phosphorus dendrimers as cores for enhanced gene delivery applications.

A protective coating strategy based on metal–organic frameworks (MOFs) has been proposed to preserve the bioactivity of the Cas12a/crRNA complex.

A novel oxygen carrier with excellent oxygen storage capacity and sustained release ability has been synthesized. This hybrid may have potential to be developed as useful artificial oxygen carriers in the future.

Ag(−)/Ag(+) clusters with negatively charged nanoparticles and big-size are transformed into positively charged nanoparticles with small size in a bacterial acidic environment to kill the bacteria effectively.

A general decoration of erythrocyte membrane-coated nanoparticles for enhanced tumor-targeting drug delivery based on the “CP–PC” interaction of MCP-PEG-FA and erythrocyte membranes.

An investigation of how the LogP value of an active controls the formation of lipid-based nanoparticles. Hydrophobically-modified drug analogues were formulated to give nanoparticles with much higher drug loadings than conventional lipid nanocarriers.

We develop hydrogels with constant composition yet different network topologies, which result in hydrogen-bond associations of different strengths and densities, as well as distinct microstructures and properties of the gels.

A brand-new tailored hCol III-based microenvironment-responsive hydrogel could effectively accelerate the repair and regeneration of chronic diabetic wounds by a programmed controlled release of therapeutic substance approach.

In situ construction of nano-structured akermanite (nAK) coatings on Ti–6Al–4V implants and their promotion for osteogenesis and osseointegration in osteoporosis.

The impact of donor strength on Bodipys’ optical properties and its applications for tumor near-infrared fluorescence imaging and photoacoustic tomography.

Radionuclide ¹³¹I-labeled gold nanoframeworks (¹³¹I-AuNFs) are developed for radiotherapy-combined second near-infrared photothermal therapy of breast cancer.

The as-prepared defective AIS/ZnS QDs have favorable oxygen-derived free radical scavenging abilities in vitro and exhibit benign anti-inflammatory activities in the model of lipopolysaccharide (LPS)-induced inflammation in macrophages.

In this study, polydopamine mesoporous nanobowls stabilise photothermally responsive oil-in water Pickering emulsions. Prepared emulsions show excellent photothermal efficiency under near-infrared (NIR) illumination, offering potential in NIR triggered drug release.

A novel GPC-3-targeted multifunctional nanoprobe for precise theranostics of orthotopic early-stage hepatocellular carcinoma was developed via dual-modal photoacoustic/magnetic resonance imaging and imaging guided non-invasive photothermal therapy.

The merger of insulin's amyloidogenic segment and an octalysine stretch produces a chimeric peptide with the ability to bind and incorporate stoichiometric amounts of ATP upon co-aggregation and formation of amyloid fibrils.

A MRI guided photothermal therapy agent Gd-DTPA-MOF-808@PANI was developed through grafting T₁-weight contrast agent Gd-DTPA molecule within the porous channel of MOF-808 and modified with polyaniline (PANI).

A non-peptide probe for detecting chymotrypsin activity based on a protection–deprotection strategy in living systems.

An electrochemical non-enzymatic sensor based on a NiVP/Pi material was developed for the selective and sensitive determination of glucose.

Reactive oxygen species (ROS) mediated tumor therapy strategies have exhibited great prospects and attracted increasing attention, among which photodynamic therapy (PDT) has been well-established.

Visualizing ONOO⁻ fluctuations in the complex drug-induced acute liver injury process using a ratiometric fluorescent probe developed by using a molecular hybridization strategy with high selectivity and sensitivity.

In this study, we aimed to achieve an efficient repair of damaged skeletal muscles using polyvinyl alcohol (PVA) soluble microneedle patches (MNP) loaded with carbonized wormwood and prostaglandin E2 (inflammatory factors).

Micro-vibration stimulation (MVs) plays a critical role in regulating the inflammatory responses of macrophages to BCP ceramics and further inducing the osteogenic differentiation of BMMSCs in a paracrine manner.

We report a multidimensional biosensor system to guide adenocarcinoma individualized treatment by integrating 2D and 3D PDC models and novel cellular impedance biosensors. The strategy may contribute to individualized treatment and drug development.

Human pluripotent stem cells can be successfully cultured on hydrogels grafted with laminin-β4 peptide having appropriate ζ potential, which have a joint segment, dual chain motif, and cationic amino acid insertion.

A multifunctional therapeutic nanoplatform for ROS-triggered NO-enhanced photothermal therapy of osteosarcoma.

The in vivo porcine carotid artery replacement studies showed that bivalirudin (BVLD) and REDV co-modified ePTFE vascular grafts could maintain ideal patency and realize endothelialization on the luminal surface at 12 weeks after implantation.

A ferroptosis nano-prodrug (SSZ–Fe²⁺@DSSD) that can generate intercellular ROS and inhibit the system x_c⁻-GSH-GPX4 pathway to enhance the cancer ferrotherapy.

The chirality of amino acids plays a key role in many biochemical processes, with the development of spectroscopic analysis methods for the chiral differentiation of amino acids being significant.

Tannic acid cross-linked dynamic hydrogels hybridized with tannic acid reduced silver nanoparticles shows multi-functional properties including dual stimuli responsive drug release, anti-bacterial and anti-reactive oxygen species abilities.

This work reports a photoelectrochemical biosensing platform for thrombin using graphene oxide-coated copper-doped zinc oxide quantum dots as the photoactive materials and glucose oxidase-encapsulated DNA nanoflowers for signal amplification.

A simple uric acid detection method is successfully developed through the integration of urate oxidase (UOx) and PCN-222(Fe) with peroxidase-like activity.

The designed Pluronic® F-127 coated Fe–TiO₂ NCs promote the growth of intestine organoids, demonstrate remarkable T₁ contrast in MRI and significant photodynamic therapy of breast cancer at very low UV power (2.5 mW cm⁻²).

Bioorthogonal chemistry in metal clusters: a new strategy for the preparation of modular multifunctional probes based on the bioorthogonal reaction system is presented.

The insufficient bioactivity of PET artificial ligaments severely weakens the ligament-bone healing in ACL reconstruction, while osteogenic modification is a prevailing method to enhance osseointegration of PET artificial ligaments.

Gene therapy provides a promising treatment for glioblastoma multiforme, which mainly depends on two key aspects, crossing the blood brain barrier (BBB) effectively and transfecting target cells selectively.

Fluorescent NH₂-MIL-125 encapsulated in a polymer was coated into wettable microwells array for the sensing of NH₃, and demonstrated a target enrichment capability and enhanced responses.

We constructed the PDA-modified HATb nanoparticle encapsulating the anticancer drug DOX (HATb-PDA-DOX), which achieved pH/NIR triggered drug release and imaging-guided synergistic chemo-photothermal tumor therapy.

We put forward an innovative strategy to construct a zwitterionic polypeptide nanocomposite which mediated unique NIR-I/II PAI and NIR-II PTT to completely eradicate MCF-7 tumors in vivo. This study will accelerate the polypeptide nanomedicine for clinical transition.

A facile and mild polydopamine (PDA) and poly(ethylene glycol) (PEG) coating strategy is reported for hydrophilic and anti-adhesive modification of porous polymer MNs from a phase inversion method.

Controlling molecular weight, crosslink density and chirality in covalent polypeptide hydrogels allows the independent tuning of rheological, water uptake, degradation and antimicrobial properties.

A facile and label-free electrochemical approach based on magnetic graphene oxide nanomaterials with a large surface to volume ratio and less susceptible to aggregation proved promising in developing highly sensitive and selective sensing of progesterone.

An oxygen-producing proenzyme hydrogel with near-infrared photoactivatable enzymatic activity was developed for photodynamic therapy enabled metastasis-inhibiting combinational therapy of breast cancer.

Bimodal sub-5 nm superparamagnetic iron oxide nanoparticles (SPIO-5) coated with polyethylene glycol of different chain lengths (i.e. PEG-800, -2000 and -5000) have been prepared and characterized.

A facile and economic method to fabricate N-rich carbon nanozyme is presented by using zein as a precursor. This material possesses intrinsic oxidase- and peroxidase-like activities, and can be applied as a robust agent for cancer treatment.

A cascade catalytic nanoplatform was established for effective chemodynamic antibacterial therapy.

A novel near-infrared fluorescent imaging probe, KSNP117, was developed. Its excellent stability and biocompatibility were confirmed in vitro and in vivo, and its biomedical application for sentinel lymph node mapping was successfully demonstrated.

The peptide TD that is conjugated to curcumin-loaded liposomes promotes the transdermal delivery and the intracellular uptake of curcumin, and thus the curcumin-loaded peptide-modified liposomes effectively enhance the inhibition of psoriasis.

Schematic illustration of PtCo NSs for enhanced tumor radiotherapy.

A microbial fuel cell bioanode encapsulating electroactive bacteria in core–shell fibers mixed with a conductive scaffold was electrospun. This new design opens up perspectives of storable ready-to-use anodes for portable applications.

Cell morphology controlled by micropatterns had different influences on gene transfection. Cell size and aspect ratio could increase gene transfection efficiency, while cell shape showed no influence.