Rhodium-catalyzed intermolecular C(sp3)–H amination in a purely aqueous system

Abstract

An efficient Rh-catalyzed intermolecular C(sp³)–H amination in a purely aqueous system is developed for the first time. This methodology features environmental benignity, broad substrate scope and versatility in late-stage functionalization of several biologically important molecules. Such an oxidation protocol provides easy access to various aliphatic amine derivatives in an efficient and sustainable manner.