Palladium-catalyzed radical cascade difluoroalkylation/cyclization of acrylamide with ethyl difluorobromoacetate†
Abstract
An efficient Pd(0)-catalyzed radical cascade difluoroalkylation/cyclization of acrylamide with ethyl difluorobromoacetate was described. In addition, the reaction can be extended to perfluoroalkyl iodides and bromodifluoromethyl phosphonate. Mechanistic studies demonstrated that a radical addition/cyclization process was involved in the sequences.
- This article is part of the themed collection: Editors’ collection: Catalytic Organic Transformations
Please wait while we load your content...
