Rh(iii)-catalyzed annulation of oxadiazolones with CF3-imidoyl sulfoxonium ylides: access to trifluoromethyl-substituted fused-dihydroisoquinolines

Abstract

A rhodium(III)-catalyzed redox-neutral C(sp²)–H bond activation and annulation of oxadiazolones and CF₃-substituted imidoyl sulfoxonium ylides (TFISYs) has been developed. A cascade C(sp²)–H bond imidoylmethylation and subsequent intramolecular nucleophilic addition sequence might be involved in the transformation, providing direct access to diverse trifluoromethyl and amino-containing fused-dihydroisoquinolines.