Issue 14, 2020
From the journal:

Dalton Transactions

A tri-metallic palladium complex with breast cancer stem cell potency†

Arvin Eskandari,‡a   Arunangshu Kundu,‡b   Alice Johnson, ORCID logo c   Sanjib Karmakar,b   Sushobhan Ghosh ORCID logo *b  and  Kogularamanan Suntharalingam ORCID logo *c  

* Corresponding authors

a School of Pharmacy, University College London, London, UK

b Department of Chemistry, Gauhati University, Guwahati, India
E-mail: sushobhan.iisc@gmail.com

c School of Chemistry, University of Leicester, Leicester, UK
E-mail: k.suntharalingam@leicester.ac.uk

Abstract

A multi-nuclear, triangular-shaped palladium(II) complex is shown to equipotently kill bulk cancer cells and cancer stem cells (CSCs) in the micromolar range. The palladium(II) complex evokes CSC apoptosis by entering CSC nuclei and damaging genomic DNA.

Graphical abstract: A tri-metallic palladium complex with breast cancer stem cell potency

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Article information

DOI
https://doi.org/10.1039/D0DT00006J
Article type
Communication
Submitted
01 Jan 2020
Accepted
07 Mar 2020
First published
09 Mar 2020

Dalton Trans., 2020,49, 4211-4215

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A tri-metallic palladium complex with breast cancer stem cell potency

A. Eskandari, A. Kundu, A. Johnson, S. Karmakar, S. Ghosh and K. Suntharalingam, Dalton Trans., 2020, 49, 4211 DOI: 10.1039/D0DT00006J

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