Tumor microenvironment responsive supramolecular glyco-nanovesicles based on diselenium-bridged pillar[5]arene dimer for targeted chemotherapy

Yang Wang; Ming Jin; Zelong Chen; Xianjun Hu; Liang Pu; Zhichao Pei; Yuxin Pei

doi:10.1039/D0CC04149A

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Tumor microenvironment responsive supramolecular glyco-nanovesicles based on diselenium-bridged pillar[5]arene dimer for targeted chemotherapy†

Yang Wang,^a Ming Jin,^a Zelong Chen,^a Xianjun Hu,^a Liang Pu,^a Zhichao Pei

^a and Yuxin Pei

*^a

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* Corresponding authors

^a Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China
E-mail: peiyx@nwafu.edu.cn
Fax: +86-29-8709-1196

Abstract

Supramolecular glyco-nanovesicles (SeSe-(P5)₂⊃Man-NH₃⁺) based on the host–guest complex of a diselenium-bridged pillar[5]arene dimer and a mannose derivative have been successfully developed for the first time, which possessed tumor microenvironment-responsiveness and specific targetability due to their diselenium bonds and mannose units, respectively.

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Article information

DOI: https://doi.org/10.1039/D0CC04149A
Article type: Communication
Submitted: 14 Jun 2020
Accepted: 29 Jul 2020
First published: 29 Jul 2020

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Chem. Commun., 2020,56, 10642-10645

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Tumor microenvironment responsive supramolecular glyco-nanovesicles based on diselenium-bridged pillar[5]arene dimer for targeted chemotherapy

Y. Wang, M. Jin, Z. Chen, X. Hu, L. Pu, Z. Pei and Y. Pei, Chem. Commun., 2020, 56, 10642 DOI: 10.1039/D0CC04149A

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Chemical Communications

Tumor microenvironment responsive supramolecular glyco-nanovesicles based on diselenium-bridged pillar[5]arene dimer for targeted chemotherapy†

Abstract

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Tumor microenvironment responsive supramolecular glyco-nanovesicles based on diselenium-bridged pillar[5]arene dimer for targeted chemotherapy

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