Silver-catalyzed ring-opening difluoromethylthiolation/trifluoromethylthiolation of cycloalkanols with PhSO2SCF2H or PhSO2SCF3

Bin Xu; Decai Wang; Yonghong Hu; Qilong Shen

doi:10.1039/C8QO00115D

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Silver-catalyzed ring-opening difluoromethylthiolation/trifluoromethylthiolation of cycloalkanols with PhSO₂SCF₂H or PhSO₂SCF₃†

Bin Xu,^a Decai Wang,^a Yonghong Hu*^a and Qilong Shen

*^b

Author affiliations

* Corresponding authors

^a Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu Province, P. R. China
E-mail: hyh@njtech.edu.cn

^b Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China
E-mail: shenql@mail.sioc.ac.cn

Abstract

A silver-catalyzed ring-opening difluoromethylthiolation/trifluoromethylthiolation of cycloalkanols including cyclopropanols, cyclobutanols, cyclopentanols, cyclohexanols and cycloheptanols was described. A variety of common functional groups such as fluoride, chloride, bromide, iodide, trifluoromethyl, cyano and ester groups were compatible.

This article is part of the themed collection: Organic Chemistry Frontiers HOT articles for 2018

Download options Please wait...

Supplementary files

Supplementary information PDF (10320K)

Article information

DOI: https://doi.org/10.1039/C8QO00115D
Article type: Research Article
Submitted: 01 Feb 2018
Accepted: 05 Mar 2018
First published: 06 Mar 2018

Download Citation

Org. Chem. Front., 2018,5, 1462-1465

Permissions

Request permissions

Silver-catalyzed ring-opening difluoromethylthiolation/trifluoromethylthiolation of cycloalkanols with PhSO₂SCF₂H or PhSO₂SCF₃

B. Xu, D. Wang, Y. Hu and Q. Shen, Org. Chem. Front., 2018, 5, 1462 DOI: 10.1039/C8QO00115D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic Chemistry Frontiers