Metal-free intermolecular aminochlorination of unactivated alkenes

Nengbo Zhu; Yajun Li; Hongli Bao

doi:10.1039/C8QO00001H

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Metal-free intermolecular aminochlorination of unactivated alkenes†

Nengbo Zhu,^a Yajun Li^a and Hongli Bao

*^a

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* Corresponding authors

^a Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, P. R. China
E-mail: hlbao@fjirsm.ac.cn

Abstract

We report a metal-free method for the synthesis of vicinal chloroamines by intermolecular aminochlorination of unactivated alkenes. This regioselective reaction is inexpensive, atom economical, and environmentally benign and tolerates various functional groups. The aminochlorinated product can be easily deprotected and subsequently transformed into valuable compounds.

This article is part of the themed collection: Celebrating Excellence in Research: Women at the Frontiers of Chemistry

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DOI: https://doi.org/10.1039/C8QO00001H
Article type: Research Article
Submitted: 02 Jan 2018
Accepted: 09 Feb 2018
First published: 09 Feb 2018

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Org. Chem. Front., 2018,5, 1303-1307

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Metal-free intermolecular aminochlorination of unactivated alkenes

N. Zhu, Y. Li and H. Bao, Org. Chem. Front., 2018, 5, 1303 DOI: 10.1039/C8QO00001H

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Metal-free intermolecular aminochlorination of unactivated alkenes†

Abstract

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Metal-free intermolecular aminochlorination of unactivated alkenes

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