Issue 11, 2018
From the journal:

Photochemical & Photobiological Sciences

Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review

Chin Siang Kue,†a   Shie Yin Ng,†b   Siew Hui Voon,c   Anyanee Kamkaew,d   Lip Yong Chung,*b   Lik Voon Kiewe  and  Hong Boon Lee*b  

* Corresponding authors

a Department of Diagnostic and Allied Health Sciences, Faculty of Health and Life Sciences, Management & Science University, 40100 Shah Alam, Selangor, Malaysia
E-mail: hongboonlee@um.edu.my, hongboonlee@gmail.com

b Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
E-mail: chungly@um.edu.my, chungly@hotmail.com

c Project Leadership, Clinical Operations, R&D Solutions, IQVIA, 50480 Kuala Lumpur, Malaysia

d School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand

e Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Abstract

BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (1O2) from molecular oxygen, leading to tissue damage in the photoirradiated region. Despite their extraordinary photophysical characteristics, they are not featured in clinical photodynamic therapy. This review discusses the recent advances in the design and/or modifications of BODIPYs since 2013, to improve their potential in photodynamic cancer therapy and related areas.

Graphical abstract: Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review

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Article information

DOI
https://doi.org/10.1039/C8PP00113H
Article type
Perspective
Submitted
18 Mar 2018
Accepted
11 May 2018
First published
14 May 2018

Photochem. Photobiol. Sci., 2018,17, 1691-1708

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Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review

C. S. Kue, S. Y. Ng, S. H. Voon, A. Kamkaew, L. Y. Chung, L. V. Kiew and H. B. Lee, Photochem. Photobiol. Sci., 2018, 17, 1691 DOI: 10.1039/C8PP00113H

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