Issue 4, 2017
From the journal:

Organic Chemistry Frontiers

Silver-catalyzed radical carbofluorination of unactivated alkenes with acetic acid in aqueous solution†

He Chen,a   Lin Zhua  and  Chaozhong Li ORCID logo *ab  

* Corresponding authors

a Key Laboratory of Organofluorine Chemistry and Collaborative Innovation Center of Chemistry for Life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
E-mail: clig@mail.sioc.ac.cn

b School of Chemical Engineering, Ningbo University of Technology, No. 89 Cuibai Road, Ningbo 315016, China

Abstract

The AgNO3-catalyzed reactions of unactivated alkenes with acetic acid and Selectfluor reagent in aqueous solution afforded the corresponding γ-fluorinated carboxylic acids under mild conditions. Carbofluorination was not only efficient and regioselective, but also enjoyed a wide functional group compatibility.

Graphical abstract: Silver-catalyzed radical carbofluorination of unactivated alkenes with acetic acid in aqueous solution

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Article information

DOI
https://doi.org/10.1039/C6QO00854B
Article type
Research Article
Submitted
26 Dec 2016
Accepted
17 Jan 2017
First published
18 Jan 2017
This article is Open Access
Creative Commons BY-NC license

Org. Chem. Front., 2017,4, 565-568

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Silver-catalyzed radical carbofluorination of unactivated alkenes with acetic acid in aqueous solution

H. Chen, L. Zhu and C. Li, Org. Chem. Front., 2017, 4, 565 DOI: 10.1039/C6QO00854B

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