Issue 49, 2013
From the journal:

Chemical Communications

Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase†

Daisuke Hayashi,a   Nobuo Kato,a   Tomohisa Kuzuyama,b   Yasuo Satoc  and  Junko Ohkanda*a  

* Corresponding authors

a The Institute of Scientific and Industrial Research (ISIR), Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan
E-mail: johkanda@sanken.osaka-u.ac.jp
Fax: +81 6 6879 8474
Tel: +81 6 6979 8472

b Biotechnology Research Center, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

c R&D Administration, Pharmaceuticals, Meiji Seika Kaisha, 2-4-16, Kyobashi, Chuo-ku, Tokyo 104-8002, Japan

Abstract

N-(2-Chlorobenzyl)-substituted hydroxamate, readily produced by hydrolysis of ketoclomazone, was identified as an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase (DXS), with an IC50 value of 1.0 μM. The compound inhibited the growth of Haemophilus influenzae. A convenient spectroscopic method for assaying DXS using NADPH–lactate dehydrogenase (LDH) is also reported.

Graphical abstract: Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase

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Article information

DOI
https://doi.org/10.1039/C3CC40758F
Article type
Communication
Submitted
29 Jan 2013
Accepted
27 Feb 2013
First published
28 Feb 2013

Chem. Commun., 2013,49, 5535-5537

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Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase

D. Hayashi, N. Kato, T. Kuzuyama, Y. Sato and J. Ohkanda, Chem. Commun., 2013, 49, 5535 DOI: 10.1039/C3CC40758F

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