A dual-targeted CeO2–DNA nanosensor for real-time imaging of H2O2 to assess atherosclerotic plaque vulnerability

Zhenhua Liu; Yujie Cao; Xiaona Zhang; Huazhen Yang; Yujie Zhao; Wen Gao; Bo Tang

doi:10.1039/C9TB02459J

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A dual-targeted CeO₂–DNA nanosensor for real-time imaging of H₂O₂ to assess atherosclerotic plaque vulnerability†

Zhenhua Liu,‡^a Yujie Cao,‡^a Xiaona Zhang,^a Huazhen Yang,^a Yujie Zhao,^a Wen Gao*^a and Bo Tang

*^a

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan, P. R. China
E-mail: gaowen@sdnu.edu.cn, tangb@sdnu.edu.cn

Abstract

A novel dual-targeted CeO₂–DNA nanosensor by modifying with folic acid (FA) and CD36 antibody was designed. This fluorescent nanosensor enables noninvasive imaging of alterations in H₂O₂in vitro and in vivo with good sensitivity and selectivity, accurately evaluating the inflammation level and providing early warning of plaque vulnerability.

This article is part of the themed collection: Biosensors

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Article information

DOI: https://doi.org/10.1039/C9TB02459J
Article type: Communication
Submitted: 03 Nov 2019
Accepted: 09 Dec 2019
First published: 10 Dec 2019

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J. Mater. Chem. B, 2020,8, 3502-3505

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A dual-targeted CeO₂–DNA nanosensor for real-time imaging of H₂O₂ to assess atherosclerotic plaque vulnerability

Z. Liu, Y. Cao, X. Zhang, H. Yang, Y. Zhao, W. Gao and B. Tang, J. Mater. Chem. B, 2020, 8, 3502 DOI: 10.1039/C9TB02459J

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Journal of Materials Chemistry B