A new method to amplify colorimetric signals of paper-based nanobiosensors for simple and sensitive pancreatic cancer biomarker detection

K. Sudhakara Prasad; Yousef Abugalyon; Chunqiang Li; Feng Xu; XiuJun Li

doi:10.1039/D0AN00704H

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A new method to amplify colorimetric signals of paper-based nanobiosensors for simple and sensitive pancreatic cancer biomarker detection†

K. Sudhakara Prasad,

‡^a Yousef Abugalyon,^a Chunqiang Li,^b Feng Xu

^c and XiuJun Li

*^ad

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* Corresponding authors

^a Department of Chemistry, University of Texas at El Paso, 500 West University Avenue, El Paso, Texas, USA
E-mail: xli4@utep.edu
Fax: +1-915-747-5748
Tel: +1-915-747-8967

^b Department of Physics, Border Biomedical Research Center, University of Texas at El Paso, 500 West University Avenue, El Paso, Texas, USA

^c Bioinspired Engineering & Biomechanics Center (BEBC), Xi'an Jiaotong University, Shaanxi, P. R. China

^d Biomedical Engineering, Border Biomedical Research Center, and Environmental Science & Engineering, University of Texas at El Paso, USA

Abstract

A low-cost, sensitive, and disposable paper-based immunosensor for instrument-free colorimetric detection of pancreatic cancer biomarker PEAK1 was reported for the first time by capitalizing the catalytic properties of gold nanoparticles in colour dye degradation. This simple signal amplification method enhances the detection sensitivity by about 10 fold.

This article is part of the themed collection: Optical Biosensor Devices

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Article information

DOI: https://doi.org/10.1039/D0AN00704H
Article type: Communication
Submitted: 08 Apr 2020
Accepted: 08 Jun 2020
First published: 17 Jun 2020

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Analyst, 2020,145, 5113-5117

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A new method to amplify colorimetric signals of paper-based nanobiosensors for simple and sensitive pancreatic cancer biomarker detection

K. S. Prasad, Y. Abugalyon, C. Li, F. Xu and X. Li, Analyst, 2020, 145, 5113 DOI: 10.1039/D0AN00704H

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A new method to amplify colorimetric signals of paper-based nanobiosensors for simple and sensitive pancreatic cancer biomarker detection†

Abstract

Supplementary files

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A new method to amplify colorimetric signals of paper-based nanobiosensors for simple and sensitive pancreatic cancer biomarker detection

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