A photocatalyst-free visible-light-promoted tandem intramolecular cyclization/heteroarylation between bromodifluoroacetamides and quinoxalin-2(1H)-ones or coumarins was developed. The process could generate a broad range of α,α-difluoro-γ-lactams.
This review focuses on the progress in catalytic asymmetric difluoroalkylation to construction of difluoroalkylated stereogenic centers. Synthetic methods, active intermediates involved and asymmetric strategies applied were summarized.
The present review focuses on recent progress (2021–2025) in EDA-enabled photocyclization for constructing various heterocyclic and carbocyclic skeletons.
A metal-free visible-light-promoted reaction of N-phenylacrylamide with bromodifluoroacetamide via electron-donor–acceptor complexes was carried out and demonstrated a broad substrate scope and good functional group tolerance.
We herein describe a photo-induced EDA-enabled multicomponent reaction of alkenes, heterocycles and Br–Rf, offering a mild alternative to traditional post modification of nitrogen heterocycles.