A sequential C–H gem-difunctionalization of 1,3-benzodioxoles with α-trifluoromethyl alkenes and electron-deficient alkenes in a redox-neutral radical polar crossover manifold have been developed for the synthesis of monofluorocyclohexenes.
A single crystal of a piperonal chalcone derivative was obtained, fully characterized, and crystallized by a slow evaporation technique.
Eight novel arylterpyridine iridium(III) complexes [Ir(N^N^N)(C^N)Cl]PF6 (Ir1–Ir8), incorporating diverse para-substituents and extended aromatic groups, were synthesized and fully characterized.
A decoupled HAT and radical capture strategy using formal copper(III) complexes enables selective C–H 18F-fluorination. The distinct selectivity arises from asynchronicity PCET, contrasting the conventional C–H activation selectivity based on BDFE.
Chalcones are indeed a versatile scaffold in medicinal chemistry.