In this review, we summarize various strategies for constructing CF2H groups based on different approaches, resulting in a series of difluoromethyl derivatives.
The review summarises various photo- and electrochemical strategies for trifluoromethylation and fluoroalkylation of different C(sp3)–H, C(sp2)–H, and C(sp)–H bonds in several classes of organic molecules.
An efficient electrochemical method has been developed for obtaining C-2 difluoromethylated indoles. A series of indole derivatives were synthesized in an undivided cell under oxidant- and catalyst-free conditions.
The incorporation of a difluoromethyl group within an aromatic ring is highly desirable.
The intermediary-produced CF2H radical, produced by one-electron oxidation of difluoromethylborates [pinB(Aryl)CF2H][K(18-cr-6)] using photo-redox catalysts, is advantageous for synthesizing the difluoromethylated benzene-fused γ-sultams.