The review highlights the use of Ugi multicomponent reactions and subsequent transformation strategies to create diverse indole frameworks in enantioselective and diastereoselective manner, underscoring their vital importance in medicinal chemistry.
This review summarizes recent advances in the combination of Ugi-4CR and dearomatization for the synthesis of spirocycles.
A two-step one-pot synthesis of 2,6-diarylmorpholin-3-ones involving Ugi reaction followed by a triflic acid-promoted intramolecular condensation accompanied by a loss of the isocyanide-originated amide moiety is described.
A one-pot strategy to prepare pyrido[1,2,3-de]quinoxaline-2,5-diones from alkynamide-containing Ugi adducts through a sequential spirocyclization and rearrangement sequence in a highly regioselective manner is reported.
Palladium-catalyzed chemo-selective tandem C–N/C–C coupling reactions to prepare pyridopyrazines from Ugi adducts.