Issue 14, 2024

Biomarkers of food intake and their relevance to metabolic syndrome

Abstract

Metabolic syndrome (MetS) constitutes a prevalent risk factor associated with non communicable diseases such as cardiovascular disease and type 2 diabetes. A major factor impacting the etiology of MetS is diet. Dietary patterns and several individual food constituents have been related to the risk of developing MetS or have been proposed as adjuvant treatment. However, traditional methods of dietary assessment such as 24 h recalls rely greatly on intensive user-interaction and are subject to bias. Hence, more objective methods are required for unbiased dietary assessment and efficient prevention. While it is accepted that some dietary-derived constituents in blood plasma are indicators for certain dietary patterns, these may be too unstable (such as vitamin C as a marker for fruits/vegetables) or too broad (e.g. polyphenols for plant-based diets) or reflect too short-term intake only to allow for strong associations with prolonged intake of individual food groups. In the present manuscript, commonly employed biomarkers of intake including those related to specific food items (e.g. genistein for soybean or astaxanthin and EPA for fish intake) and novel emerging ones (e.g. stable isotopes for meat intake or microRNA for plant foods) are emphasized and their suitability as biomarker for food intake discussed. Promising alternatives to plasma measures (e.g. ethyl glucuronide in hair for ethanol intake) are also emphasized. As many biomarkers (i.e. secondary plant metabolites) are not limited to dietary assessment but are also capable of regulating e.g. anti-inflammatory and antioxidant pathways, special attention will be given to biomarkers presenting a double function to assess both dietary patterns and MetS risk.

Graphical abstract: Biomarkers of food intake and their relevance to metabolic syndrome

Article information

Article type
Review Article
Submitted
13 Feb 2024
Accepted
29 May 2024
First published
07 Jun 2024
This article is Open Access
Creative Commons BY license

Food Funct., 2024,15, 7271-7304

Biomarkers of food intake and their relevance to metabolic syndrome

M. Cifuentes, F. Vahid, Y. Devaux and T. Bohn, Food Funct., 2024, 15, 7271 DOI: 10.1039/D4FO00721B

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