Issue 74, 2024

Wireless asymmetric umpolung electrosynthesis

Abstract

Electroorganic synthesis has become an exciting tool for the asymmetric conversion of pro-chiral compounds. Herein, we introduced a wireless methodology based on bipolar electrochemistry in synergy with the enantioselective capabilities of inherently chiral oligomers to induce an umpolung chirality transfer. This was exemplified by the electro-conversion of a racemic mixture of lansoprazole to an enantio-enriched solution of a single antipode.

Graphical abstract: Wireless asymmetric umpolung electrosynthesis

Supplementary files

Article information

Article type
Communication
Submitted
17 May 2024
Accepted
01 Jul 2024
First published
01 Jul 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 10120-10123

Wireless asymmetric umpolung electrosynthesis

S. Grecchi, B. Bonczak, F. Malacarne, G. Salinas, R. Cirilli and S. Arnaboldi, Chem. Commun., 2024, 60, 10120 DOI: 10.1039/D4CC02406K

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