Asymmetric synthesis of 2,2-disubstituted indolin-3-ones has attracted much attention due to their presence in many important compounds. Herein, we discuss this unit's current state of asymmetric synthetic methods under different catalytic systems.
The present review highlights the dearomatization of indoles by oxidizing C–H bonds for constructing oxindoles skeletons. Various synthetic approaches have been summarized followed by their applications in indole alkaloids and bioactive compounds.
Herein, the synthesis of 2-(3,3-difluoro-2-phenylindolin-2-yl)-1-phenylethan-1-one scaffolds through asymmetric Mannich reactions between 3,3-difluoro cyclic ketimines and simple ketones is described.
This review will focus on the electrochemical synthesis of diversified functionalized oxindole derivatives through C-S, C-O, C-C, C-Se, and C-N bond formation over the past decade.
Highly efficient synthesis of diverse 2,2-disubstituted 3-methyleneindoline derivatives through a one-pot base-promoted post-Ugi 5-exo-dig “Conia-ene”-type cyclization has been disclosed.