A simple and novel solid-supported organocatalyst from a 2-chlorotrityl chloride resin-immobilized 4-hydroxyproline was developed, which has been used for the asymmetric Mannich reaction of 2-aryl-3H-indol-3-ones and aldehydes/ketones.
An efficient metal-free, (NH4)2S2O8 mediated oxidative dearomatization of indoles for construction of C2-quaternary indolinones was disclosed which provides an approach for generation of all-carbon quaternary centers at the C2 position of indoles.
Asymmetric synthesis of 2,2-disubstituted indolin-3-ones has attracted much attention due to their presence in many important compounds. Herein, we discuss this unit's current state of asymmetric synthetic methods under different catalytic systems.
Herein, the synthesis of 2-(3,3-difluoro-2-phenylindolin-2-yl)-1-phenylethan-1-one scaffolds through asymmetric Mannich reactions between 3,3-difluoro cyclic ketimines and simple ketones is described.
The present review highlights the dearomatization of indoles by oxidizing C–H bonds for constructing oxindoles skeletons. Various synthetic approaches have been summarized followed by their applications in indole alkaloids and bioactive compounds.