SliceChip: a benchtop fluidic platform for organotypic culture and serial assessment of human and rodent pancreatic slices

Charles G. Alver, Silvia Álvarez-Cubela, Isabella Altilio, Emily Hutchison, Emma Warrner, Mariana E. Viso, Giana Vitale, David Oliver, Ricardo L. Pastori, Juan Dominguez-Bendala and Ashutosh Agarwal

Lab Chip, 2024, 24, 1557
DOI: 10.1039/D3LC00850A

A lung tumor-on-a-chip model recapitulates the effect of hypoxia on radiotherapy response and FDG-PET imaging

Rohollah Nasiri, Myra Kurosu Jalil, Veronica Ibanez Gaspar, Andrea Sofia Flores Perez, Hieu Thi Minh Nguyen, Syamantak Khan, Sindy K. Y. Tang, Yunzhi Peter Yang and Guillem Pratx

Lab Chip, 2025, 25, 4677
DOI: 10.1039/D5LC00373C

A microphysiological system for studying human bone biology under simultaneous control of oxygen tension and mechanical loading

Julia Scheinpflug, Chris Tina Höfer, Sarah S. Schmerbeck, Matthias Steinfath, Jennifer Doka, Yonatan Afework Tesfahunegn, Norman Violet, Kostja Renko, Konrad Gulich, Thilo John, Marlon R. Schneider, Elisa Wistorf, Gilbert Schönfelder and Frank Schulze

Lab Chip, 2023, 23, 3405
DOI: 10.1039/D3LC00154G

Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models

Lei Wu, Yongjian Ai, Ruoxiao Xie, Jialiang Xiong, Yu Wang and Qionglin Liang

Lab Chip, 2023, 23, 1192
DOI: 10.1039/D2LC00804A

Microphysiological pancreas-on-chip platform with integrated sensors to model endocrine function and metabolism

Katharina Schlünder, Madalena Cipriano, Aline Zbinden, Stefanie Fuchs, Torsten Mayr, Katja Schenke-Layland and Peter Loskill

Lab Chip, 2024, 24, 2080
DOI: 10.1039/D3LC00838J

Liver organ-on-chip models for toxicity studies and risk assessment

Taha Messelmani, Lisa Morisseau, Yasuyuki Sakai, Cécile Legallais, Anne Le Goff, Eric Leclerc and Rachid Jellali

Lab Chip, 2022, 22, 2423
DOI: 10.1039/D2LC00307D

Microsensor systems for cell metabolism – from 2D culture to organ-on-chip (2019–2024)

Johannes Dornhof, Jochen Kieninger, Stefan J. Rupitsch and Andreas Weltin

Lab Chip, 2025, 25, 1149
DOI: 10.1039/D4LC00437J

Precise and fast control of the dissolved oxygen level for tumor-on-chip

Charlotte Bouquerel, William César, Lara Barthod, Sarah Arrak, Aude Battistella, Giacomo Gropplero, Fatima Mechta-Grigoriou, Gérard Zalcman, Maria Carla Parrini, Marine Verhulsel and Stéphanie Descroix

Lab Chip, 2022, 22, 4443
DOI: 10.1039/D2LC00696K

Antibacterial microneedle patch releases oxygen to enhance diabetic wound healing

Mengli Sun, Xiqiang Zhong, Minghai Dai, Xujun Feng, Chengxuan Tang, Lingling Cao and Liangle Liu

Materials Today Bio, 2024, 24, 100945
DOI: 10.1016/j.mtbio.2024.100945

Remotephotoplethysmography‐basedhuman vital sign prediction using cyclical algorithm

Kapil Gupta, Ruchika Sinhal and Sagarkumar S. Badhiye

Journal of Biophotonics, 2024, 17
DOI: 10.1002/jbio.202300286

Mathematical modelling of oxygen transport in a muscle-on-chip device

David Hardman, Manh-Louis Nguyen, Stéphanie Descroix and Miguel O. Bernabeu

Interface Focus., 2022, 12
DOI: 10.1098/rsfs.2022.0020

A 3D-printed multi-channel microfluidic device for precise dissolved oxygen regulation in cancer hypoxia research

Chenchen Zhang, Ziyi Yu, Haiyang Tang, Kuo Tian, Min Jiang, Zhoumin Li and Danke Xu

Talanta, 2026, 296, 128469
DOI: 10.1016/j.talanta.2025.128469

Scaffold-based 3D cell culture models in cancer research

Waad H. Abuwatfa, William G. Pitt and Ghaleb A. Husseini

J Biomed Sci, 2024, 31
DOI: 10.1186/s12929-024-00994-y

Biological characterization of breast cancer spheroid formed by fast fabrication method

Yuta Iijima, Norino Uenaka, Mayu Morimoto, Daiki Sato, Satomi Hirose, Naoyoshi Sakitani, Masahiro Shinohara, Kenichi Funamoto, Gen Hayase and Daisuke Yoshino

In vitro models, 2024, 3, 19
DOI: 10.1007/s44164-024-00066-3

Detecting Nanotopography Induced Changes in Cell Migration Directions Using Oxygen Sensors

Muting Wang and Stella W. Pang

Biosensors, 2024, 14, 389
DOI: 10.3390/bios14080389

Gas transport mechanisms through gas-permeable membranes in microfluidics: A perspective

Sangjin Seo and Taesung Kim

Biomicrofluidics, 2023, 17
DOI: 10.1063/5.0169555

A three-zone hypoxia chamber capable of regulating unique oxygen and carbon dioxide partial pressures simultaneously

Zachary R. Sitte, Abel A. Miranda, Thomas J. DiProspero and Matthew R. Lockett

HardwareX, 2024, 19, e00556
DOI: 10.1016/j.ohx.2024.e00556

Deciphering variations in the endocytic uptake of a cell-penetrating peptide: the crucial role of cell culture protocols

Joshua Diaz and Jean-Philippe Pellois

Cytotechnology, 2023, 75, 473
DOI: 10.1007/s10616-023-00591-1

Microfluidic oxygen gradient assay unveils metabolic shifts in HaCaT cell migration under diabetic conditions

Mohamad Orabi, Kai Duan, Mengyang Zhou and Joe Fujiou Lo

Integrative Biology, 2025, 17
DOI: 10.1093/intbio/zyaf006

Organ-on-a-chip systems for modeling tumor and normal tissue microenvironments in radiotherapy research

Rohollah Nasiri, Arnav Sankaranthi and Guillem Pratx

Trends in Biotechnology, 2025
DOI: 10.1016/j.tibtech.2025.07.002

Organ-on-a-chip models for development of cancer immunotherapies

M. Chernyavska, M. Masoudnia, T. Valerius and W. P. R. Verdurmen

Cancer Immunol Immunother, 2023, 72, 3971
DOI: 10.1007/s00262-023-03572-7

Compartmentalized organ-on-a-chip structure for spatiotemporal control of oxygen microenvironments

Kaisa Tornberg, Hannu Välimäki, Silmu Valaskivi, Antti-Juhana Mäki, Matias Jokinen, Joose Kreutzer and Pasi Kallio

Biomed Microdevices, 2022, 24
DOI: 10.1007/s10544-022-00634-y

Prototyping in Polymethylpentene to Enable Oxygen-Permeable On-a-Chip Cell Culture and Organ-on-a-Chip Devices Suitable for Microscopy

Linda Sønstevold, Paulina Koza, Maciej Czerkies, Erik Andreassen, Paul McMahon and Elizaveta Vereshchagina

Micromachines, 2024, 15, 898
DOI: 10.3390/mi15070898

Application of Polymethylpentene, an Oxygen Permeable Thermoplastic, for Long-Term on-a-Chip Cell Culture and Organ-on-a-Chip Devices

Linda Sønstevold, Maciej Czerkies, Enrique Escobedo-Cousin, Slawomir Blonski and Elizaveta Vereshchagina

Micromachines, 2023, 14, 532
DOI: 10.3390/mi14030532

Microfluidic Platform with Local Oxygen Sensors Demonstrates That 3D Blood Vessel Networks Exhibit Time‐Dependent Changes in Oxygen Concentrations During Their Formation and Perfusion

Tarek Gensheimer, Stefanie Fuchs, Laura E. de Heus, Kim Vermeul, Torsten Mayr and Andries v.d. Meer

Adv Materials Technologies, 2025
DOI: 10.1002/admt.202500194

TargetingDNAtopoisomeraseIIα(TOP2A) in the hypoxic tumour microenvironment using unidirectional hypoxia‐activated prodrugs (uHAPs)

Paul J. Smith, Stephanie R. McKeown and Laurence H. Patterson

IUBMB Life, 2023, 75, 40
DOI: 10.1002/iub.2619

Validation of HepG2/C3A Cell Cultures in Cyclic Olefin Copolymer Based Microfluidic Bioreactors

Leire Etxeberria, Taha Messelmani, Jon Haitz Badiola, Andreu Llobera, Luis Fernandez, José Luis Vilas-Vilela, Eric Leclerc, Cécile Legallais, Rachid Jellali and Ane Miren Zaldua

Polymers, 2022, 14, 4478
DOI: 10.3390/polym14214478

A Comprehensive Review of Biosensor Integration in Microphysiological Systems for Online Monitoring: Current Challenges and Future Advancements

Fida Hussain Memon, Kang Inseok, Faheem Ahmed, Wajid Ali, Afaque Manzoor Soomro, Saleem Raza Memon, Kashif Hussain Memon and Kyung Hyun Choi

ChemBioEng Reviews, 2023, 10, 817
DOI: 10.1002/cben.202200066

Microfluidics for 3D Cell and Tissue Cultures: Microfabricative and Ethical Aspects Updates

Tania Limongi, Francesco Guzzi, Elvira Parrotta, Patrizio Candeloro, Stefania Scalise, Valeria Lucchino, Francesco Gentile, Luca Tirinato, Maria Laura Coluccio, Bruno Torre, Marco Allione, Monica Marini, Francesca Susa, Enzo Di Fabrizio, Giovanni Cuda and Gerardo Perozziello

Cells, 2022, 11, 1699
DOI: 10.3390/cells11101699

Oxygen Gradient Induced in Microfluidic Chips Can Be Used as a Model for Liver Zonation

Shahrouz Ghafoory, Christina Stengl, Stefan Kopany, Mert Mayadag, Nils Mechtel, Brennah Murphy, Sebastian Schattschneider, Niklas Wilhelmi and Stefan Wölfl

Cells, 2022, 11, 3734
DOI: 10.3390/cells11233734

Fibrosis‐on‐Chip: A Guide to Recapitulate the Essential Features of Fibrotic Disease

Emma M. Streutker, Utku Devamoglu, Madelon C. Vonk, Wouter P. R. Verdurmen and Séverine Le Gac

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202303991

Hypoxia in myocardial infarction and natriuretic peptides

Olli Arjamaa

Open Heart, 2025, 12, e003130
DOI: 10.1136/openhrt-2024-003130