Investigating the trans-membrane transport of HAIYPRH peptide-decorated nano-drugs

Xiaowan Zhang; Meirong Shan; Siying Li; Jing Zhao; Xuelei Pang; Guocheng Yang; Yuping Shan

doi:10.1039/D3CP00342F

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Investigating the trans-membrane transport of HAIYPRH peptide-decorated nano-drugs†

Xiaowan Zhang,^a Meirong Shan,^a Siying Li,^a Jing Zhao,^a Xuelei Pang,^a Guocheng Yang^a and Yuping Shan

*^a

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* Corresponding authors

^a School of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China
E-mail: shanyp@ciac.ac.cn

Abstract

Transferrin (Tf) has been effectively used to promote the cellular uptake of HAIYPRH (T7) peptide-conjugated nano-drugs. In this study, the enhancing effect of Tf on T7-decorated nano-drug transport was investigated using force tracing and nano-indentation techniques at a single-particle/cell level. Furthermore, the results were confirmed by ensemble fluorescence imaging.

This article is part of the themed collections: 2023 PCCP HOT Articles and Emerging concepts in nucleic acids: structures, functions and applications

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DOI: https://doi.org/10.1039/D3CP00342F
Article type: Communication
Submitted: 21 Jan 2023
Accepted: 09 Mar 2023
First published: 09 Mar 2023

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Phys. Chem. Chem. Phys., 2023,25, 9766-9771

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Investigating the trans-membrane transport of HAIYPRH peptide-decorated nano-drugs

X. Zhang, M. Shan, S. Li, J. Zhao, X. Pang, G. Yang and Y. Shan, Phys. Chem. Chem. Phys., 2023, 25, 9766 DOI: 10.1039/D3CP00342F

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Physical Chemistry Chemical Physics

Investigating the trans-membrane transport of HAIYPRH peptide-decorated nano-drugs†

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Investigating the trans-membrane transport of HAIYPRH peptide-decorated nano-drugs

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