Cheminformatics-guided optimization of the antimalarial activity and physicochemical properties of 2,4-diaminopyrimidines.
A visible light-induced difluoroalkylation/heteroarylation of [1.1.1]propellane with nitrogen containing heterocycles and difluoroiodane(III) reagents was achieved.
A convenient visible-light-promoted difluoromethylation/cyclization reaction to access various difluoromethylated benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones was developed using [Ph3PCF2H]+Br− as a difluoromethylated reagent.
A new series of 5-(thiophen-2-yl)isoxazoles has been designed, synthesized, and subjected to in vitro anti-cancer screening, which revealed a new molecule, TTI-6, to be the best anti-breast cancer agent (IC50 = 1.91 μM against MCF-7) among others.
This review summarizes chemical tools for cell engineering, introduces their wide application in diagnosis and therapy, and discusses the challenges and opportunities in precision medicine.