Aminoglycoside-induced lipotoxicity and its reversal in kidney on chip

Konstantinos Ioannidis, Aaron Cohen, Mohammad Ghosheh, Avner Ehrlich, Amit Fischer, Merav Cohen and Yaakov Nahmias

Lab Chip, 2022, 22, 4469
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Microfluidic-Based Oxygen (O2) Sensors for On-Chip Monitoring of Cell, Tissue and Organ Metabolism

Mostafa Azimzadeh, Patricia Khashayar, Meitham Amereh, Nishat Tasnim, Mina Hoorfar and Mohsen Akbari

Biosensors, 2021, 12, 6
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Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D in vitro tissue models of disease

Jose L. Cadavid, Nancy T. Li and Alison P. McGuigan

Biophysics Reviews, 2024, 5
DOI: 10.1063/5.0179125

Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids

Mohammad Ghosheh, Avner Ehrlich, Konstantinos Ioannidis, Muneef Ayyash, Idit Goldfracht, Merav Cohen, Amit Fischer, Yoav Mintz, Lior Gepstein and Yaakov Nahmias

Nat. Biomed. Eng, 2023, 7, 1493
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Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development—Current State-of-the-Art and Future Perspectives

Sonia Youhanna, Aurino M. Kemas, Lena Preiss, Yitian Zhou, Joanne X. Shen, Selgin D. Cakal, Francesco S. Paqualini, Sravan K. Goparaju, Reza Zandi Shafagh, Johan Ulrik Lind, Carl M. Sellgren and Volker M. Lauschke

Pharmacological Reviews, 2022, 74, 141
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State-of-the-art liver disease research using liver-on-a-chip

Sayaka Deguchi and Kazuo Takayama

Inflamm Regener, 2022, 42
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Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment

Filipa Lebre, Nivedita Chatterjee, Samantha Costa, Eli Fernández-de-Gortari, Carla Lopes, João Meneses, Luís Ortiz, Ana R. Ribeiro, Vânia Vilas-Boas and Ernesto Alfaro-Moreno

Nanomaterials, 2022, 12, 1810
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Role of synthetical amynoquinone ethyl 2-(1,4-dioxo-1,4-dihydronaphthalen-2-ylamino) acetate in inhibition of Ehrlich’s tumor

Thiago Augusto Pereira de Moraes, Fernanda Carolina Ribeiro Dias, Maria José Sarmento - Filha, Celso de Amorim Camara, Tania Maria Sarmento Silva, Sandra Maria Torres, Ivone Antônia Souza, Márcia de Figueiredo Pereira, Danielle Barbosa Morais and Valdemiro Amaro Silva Junior

Pathology - Research and Practice, 2023, 241, 154272
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Liver–Heart on chip models for drug safety

Erika Ferrari and Marco Rasponi

APL Bioengineering, 2021, 5
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Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

Naina Sunildutt, Pratibha Parihar, Abdul Rahim Chethikkattuveli Salih, Sang Ho Lee and Kyung Hyun Choi

Front. Pharmacol., 2023, 14
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Human organs-on-chips for disease modelling, drug development and personalized medicine

Donald E. Ingber

Nat Rev Genet, 2022, 23, 467
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A Human Liver‐on‐a‐Chip Platform for Modeling Nonalcoholic Fatty Liver Disease

Soufian Lasli, Han‐Jun Kim, KangJu Lee, Ceri‐Anne E. Suurmond, Marcus Goudie, Praveen Bandaru, Wujin Sun, Shiming Zhang, Niyuan Zhang, Samad Ahadian, Mehmet R. Dokmeci, Junmin Lee and Ali Khademhosseini

Adv. Biosys., 2019, 3
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Modeling Colorectal Cancer-Induced Liver Portal Vein Microthrombus on a Hepatic Lobule Chip

Xiaofang Du, Rong Zou, Kun Du, Dabing Huang, Chunguang Miao, Bensheng Qiu, Weiping Ding and Chengpan Li

ACS Appl. Mater. Interfaces, 2023
DOI: 10.1021/acsami.3c14417

Microneedle array facilitates hepatic sinusoid construction in a large-scale liver-acinus-chip microsystem

Shibo Li, Chengpan Li, Muhammad Imran Khan, Jing Liu, Zhengdi Shi, Dayong Gao, Bensheng Qiu and Weiping Ding

Microsyst Nanoeng, 2023, 9
DOI: 10.1038/s41378-023-00544-w

A review of current state-of-the-art materiobiology and technological approaches for liver tissue engineering

Shadil Ibrahim Wani, Tanveer Ahmad Mir, Makoto Nakamura, Tomoshi Tsuchiya, Alaa Alzhrani, Shintaroh Iwanaga, Kenichi Arai, Eman A. Alshehri, Talal Shamma, Dalia A. Obeid, Raja Chinnappan, Abdullah M. Assiri, Ahmed Yaqinuddin, Yogesh K. Vashist and Dieter C. Broering

Bioprinting, 2024, 42, e00355
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Microfluidic systems for modeling human development

Makenzie G. Bonner, Hemanth Gudapati, Xingrui Mou and Samira Musah

Development, 2022, 149
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Development of digital organ-on-a-chip to assess hepatotoxicity and extracellular vesicle-based anti-liver cancer immunotherapy

Guohua Wu, Jianguo Wu, Zihan Li, Shengyu Shi, Di Wu, Xuanbo Wang, Han Xu, Hui Liu, Yixiao Huang, Rending Wang, Jia Shen, Zhihong Dong and Shuqi Wang

Bio-des. Manuf., 2022, 5, 437
DOI: 10.1007/s42242-022-00188-1

Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study

Avner Ehrlich, Konstantinos Ioannidis, Makram Nasar, Ismaeel Abu Alkian, Yuval Daskal, Nofar Atari, Limor Kliker, Nir Rainy, Matan Hofree, Sigal Shafran Tikva, Inbal Houri, Arrigo Cicero, Chiara Pavanello, Cesare R Sirtori, Jordana B Cohen, Julio A Chirinos, Lisa Deutsch, Merav Cohen, Amichai Gottlieb, Adina Bar-Chaim, Oren Shibolet, Michal Mandelboim, Shlomo L Maayan and Yaakov Nahmias

eLife, 2023, 12
DOI: 10.7554/eLife.79946

Liver‐on‐a‐Chip Models of Fatty Liver Disease

Shabir Hassan, Shikha Sebastian, Sushila Maharjan, Ami Lesha, Anne‐Marie Carpenter, Xiuli Liu, Xin Xie, Carol Livermore, Yu Shrike Zhang and Ali Zarrinpar

Hepatology, 2020, 71, 733
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Human biomimetic liver microphysiology systems in drug development and precision medicine

Albert Gough, Alejandro Soto-Gutierrez, Lawrence Vernetti, Mo R. Ebrahimkhani, Andrew M. Stern and D. Lansing Taylor

Nat Rev Gastroenterol Hepatol, 2021, 18, 252
DOI: 10.1038/s41575-020-00386-1

Modeling nonalcoholic fatty liver disease on a liver lobule chip with dual blood supply

Kun Du, Shibo Li, Chengpan Li, Ping Li, Chunguang Miao, Tianzhi Luo, Bensheng Qiu and Weiping Ding

Acta Biomaterialia, 2021, 134, 228
DOI: 10.1016/j.actbio.2021.07.013

Challenges and Opportunities in the Design of Liver-on-Chip Microdevices

Avner Ehrlich, Daniel Duche, Gladys Ouedraogo and Yaakov Nahmias

Annu. Rev. Biomed. Eng., 2019, 21, 219
DOI: 10.1146/annurev-bioeng-060418-052305

Quercetin and hydroxytyrosol as modulators of hepatic steatosis: A NAFLD‐on‐a‐chip study

Manuele Gori, Sara Maria Giannitelli, Andrea Zancla, Pamela Mozetic, Marcella Trombetta, Nicolò Merendino and Alberto Rainer

Biotech & Bioengineering, 2021, 118, 142
DOI: 10.1002/bit.27557

Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization

Shan Liu, Shikha Kumari, Hongyi He, Parichita Mishra, Bhisham Narayan Singh, Divakar Singh, Sutong Liu, Pradeep Srivastava and Chenzhong Li

Biosensors and Bioelectronics, 2023, 231, 115285
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State-of-the-art advancements in Liver-on-a-chip (LOC): Integrated biosensors for LOC

Min Liu, Yuting Xiang, Yuqi Yang, Xingyu Long, Zuoxiu Xiao, Yayun Nan, Yitian Jiang, Yige Qiu, Qiong Huang and Kelong Ai

Biosensors and Bioelectronics, 2022, 218, 114758
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Mechanism and reversal of drug-induced nephrotoxicity on a chip

Aaron Cohen, Konstantinos Ioannidis, Avner Ehrlich, Shaun Regenbaum, Merav Cohen, Muneef Ayyash, Sigal Shafran Tikva and Yaakov Nahmias

Sci. Transl. Med., 2021, 13
DOI: 10.1126/scitranslmed.abd6299

Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors

Manush Saydmohammed, Anupma Jha, Vineet Mahajan, Dillon Gavlock, Tong Ying Shun, Richard DeBiasio, Daniel Lefever, Xiang Li, Celeste Reese, Erin E Kershaw, Vijay Yechoor, Jaideep Behari, Alejandro Soto-Gutierrez, Larry Vernetti, Andrew Stern, Albert Gough, Mark T Miedel and D Lansing Taylor

Exp Biol Med (Maywood), 2021, 246, 2420
DOI: 10.1177/15353702211009228

Recent advances in liver‐on‐chips: Design, fabrication, and applications

Linjie Qiu, Bin Kong, Tiantian Kong and Huan Wang

Smart Medicine, 2023, 2
DOI: 10.1002/SMMD.20220010