Issue 30, 2023
From the journal:

Chemical Communications

Imidazole–carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging†

Thanh Chung Pham, ORCID logo a   Dong Joon Lee,b   Do Hun Kim,c   Juyoung Yoon, ORCID logo d   Tran Dai Lam, ORCID logo a   Hwan Myung Kim ORCID logo *be  and  Songyi Lee ORCID logo *cf  

* Corresponding authors

a Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

b Department of Chemistry, Ajou University, Suwon 16400, Korea
E-mail: kimhm@ajou.ac.kr

c Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Korea
E-mail: slee@pknu.ac.kr

d Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea

e Department of Energy Systems Research, Ajou University, Suwon 16499, Korea

f Department of Chemistry, Pukyong National University, Busan 48513, Korea

Abstract

A heavy-atom-free photosensitizer (CI) based on an imidazole–carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.

Graphical abstract: Imidazole–carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging

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Article information

DOI
https://doi.org/10.1039/D3CC00108C
Article type
Communication
Submitted
08 Jan 2023
Accepted
20 Mar 2023
First published
20 Mar 2023

Chem. Commun., 2023,59, 4503-4506

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Imidazole–carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging

T. C. Pham, D. J. Lee, D. H. Kim, J. Yoon, T. D. Lam, H. M. Kim and S. Lee, Chem. Commun., 2023, 59, 4503 DOI: 10.1039/D3CC00108C

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