Issue 30, 2016
From the journal:

Chemical Communications

Self-assembly of a 5-fluorouracil-dipeptide hydrogel†

Yuan Sun, ORCID logo a   Jonah A. Kaplan,b   Aileen Shieh,a   Hui-Lung Sun,c   Carlo M. Croce,c   Mark W. Grinstaff*b  and  Jon R. Parquette*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, Ohio 43210, USA
E-mail: parquett@chemistry.ohio-state.edu
Fax: +1 614 292-1685

b Departments of Biomedical Engineering and Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA
E-mail: mgrin@bu.edu

c Department of Molecular Virology Immunology and Medical Genetics, The Ohio State University, 460 W. 12th Ave., Columbus, OH 43210, USA

Abstract

The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates was highly dependent on concentration in solution, whereas, release from the fully formed hydrogels was significantly slower. The 5-Fu conjugate also exhibited promising in vitro cytotoxicity against human tumor cell lines A549, H460 and H23.

Graphical abstract: Self-assembly of a 5-fluorouracil-dipeptide hydrogel

  • This article is part of the themed collection: Foldamers
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Article information

DOI
https://doi.org/10.1039/C6CC01195K
Article type
Communication
Submitted
05 Feb 2016
Accepted
04 Mar 2016
First published
09 Mar 2016

Chem. Commun., 2016,52, 5254-5257

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Self-assembly of a 5-fluorouracil-dipeptide hydrogel

Y. Sun, J. A. Kaplan, A. Shieh, H. Sun, C. M. Croce, M. W. Grinstaff and J. R. Parquette, Chem. Commun., 2016, 52, 5254 DOI: 10.1039/C6CC01195K

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