Issue 33, 2024

Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles

Abstract

The application of mRNA therapy is constrained by the current lipid nanoparticles' (LNPs) inability to target non-liver tissues. In this study, we demonstrate that ionizable lipids equipped with branched and biodegradable tails enhance the selective delivery of mRNA to the spleen, particularly to antigen-presenting cells. This approach offers novel insights into how the chemical structure of LNPs influences their organ-specific targeting capabilities.

Graphical abstract: Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
05 May 2024
Accepted
22 Jul 2024
First published
23 Jul 2024

J. Mater. Chem. B, 2024,12, 8062-8066

Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles

Y. Ren, L. Zeng, Y. Tang, J. Liao, M. Jiang, X. Cao, H. Fan and J. Chen, J. Mater. Chem. B, 2024, 12, 8062 DOI: 10.1039/D4TB00960F

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