Issue 15, 2024

Application of quantum dots in brain diseases and their neurotoxic mechanism

Abstract

The early-stage diagnosis and therapy of brain diseases pose a persistent challenge in the field of biomedicine. Quantum dots (QDs), nano-luminescent materials known for their small size and fluorescence imaging capabilities, present promising capabilities for diagnosing, monitoring, and treating brain diseases. Although some investigations about QDs have been conducted in clinical trials, the concerns about the toxicity of QDs have continued. In addition, the lack of effective toxicity evaluation methods and systems and the difference between in vivo and in vitro toxicity evaluation hinder QDs application. The primary objective of this paper is to introduce the neurotoxic effects and mechanisms attributable to QDs. First, we elucidate the utilization of QDs in brain disorders. Second, we sketch out three pathways through which QDs traverse into brain tissue. Ultimately, expound upon the adverse consequences of QDs on the brain and the mechanism of neurotoxicity in depth. Finally, we provide a comprehensive summary and outlook on the potential development of quantum dots in neurotoxicity and the difficulties to be overcome.

Graphical abstract: Application of quantum dots in brain diseases and their neurotoxic mechanism

Article information

Article type
Review Article
Submitted
10 Jan 2024
Accepted
01 Jun 2024
First published
05 Jun 2024
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2024,6, 3733-3746

Application of quantum dots in brain diseases and their neurotoxic mechanism

Y. Hu, X. Wang, Y. Niu, K. He and M. Tang, Nanoscale Adv., 2024, 6, 3733 DOI: 10.1039/D4NA00028E

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