Issue 19, 2024

Nisin-relevant antimicrobial peptides: synthesis strategies and applications

Abstract

Small pentacyclic peptides, represented by nisin, have been successfully utilized as preservatives in the food industry and have evolved into a paradigm for understanding the genetic structure, expression, and control of genes created by lantibiotics. Due to the ever-increasing antibiotic resistance, nisin-relevant antimicrobial peptides have received much attention, which calls for a summarization of their synthesis, modification and applications. In this review, we first provided a timeline of select highlights in nisin biosynthesis and engineering. Then, we outlined the current developments in nisin synthesis. We also provided an overview of the engineering, screening, and production of nisin-relevant antimicrobial peptides based on enzyme alteration, substrate modification, and sequence mining. Furthermore, an updated summary of applications of nisin-relevant antimicrobial peptides has been developed for food applications. Finally, this study offers insights into emerging technologies, limitations and the future development of nisin-relevant antimicrobial peptides for pathogen inhibition, food preservatives, and improved health.

Graphical abstract: Nisin-relevant antimicrobial peptides: synthesis strategies and applications

Article information

Article type
Review Article
Submitted
19 Dec 2023
Accepted
28 Mar 2024
First published
07 Jun 2024

Food Funct., 2024,15, 9662-9677

Nisin-relevant antimicrobial peptides: synthesis strategies and applications

L. Yuan, S. Wu, K. Tian, S. Wang, H. Wu and J. Qiao, Food Funct., 2024, 15, 9662 DOI: 10.1039/D3FO05619H

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