Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(III) glycoconjugate systems

Karolina Wojtczak; Eva Zahorska; Ian J. Murphy; Finnja Koppel; Gordon Cooke; Alexander Titz; Joseph P. Byrne

doi:10.1039/D3CC02300A

Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(iii) glycoconjugate systems†

Karolina Wojtczak,

^a Eva Zahorska,

^bcd Ian J. Murphy,^a Finnja Koppel,^e Gordon Cooke,

^e Alexander Titz

^bcd and Joseph P. Byrne

*^af

Author affiliations

* Corresponding authors

^a School of Biological and Chemical Sciences, University of Galway, University Road, Galway, Ireland
E-mail: Joseph.byrne@ucd.ie

^b Chemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, Saarbrücken D-66123, Germany

^c Department of Chemistry, Saarland University, Saarbrücken D-66123, Germany

^d Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, Braunschweig, Germany

^e School of Chemical & BioPharmaceutical Sciences, Technological University Dublin, Dublin, Ireland

^f School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland

Abstract

Interactions of lectins with glycoconjugate-terbium(III) self-assembly complexes lead to sensing through enhanced lanthanide luminescence. This glycan-directed sensing paradigm detects an unlabelled lectin (LecA) associated with pathogen P. aeruginosa in solution, without any bactericidal activity. Further development of these probes could have potential as a diagnostic tool.

This article is part of the themed collections: Chemical Communications HOT Articles 2023 and Chemosensors and Molecular Logic

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Article information

DOI: https://doi.org/10.1039/D3CC02300A
Article type: Communication
Submitted: 11 May 2023
Accepted: 08 Jun 2023
First published: 08 Jun 2023
This article is Open Access

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Chem. Commun., 2023,59, 8384-8387

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Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(III) glycoconjugate systems

K. Wojtczak, E. Zahorska, I. J. Murphy, F. Koppel, G. Cooke, A. Titz and J. P. Byrne, Chem. Commun., 2023, 59, 8384 DOI: 10.1039/D3CC02300A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(iii) glycoconjugate systems†

Abstract

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Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(III) glycoconjugate systems

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