Copper-catalyzed three-component oxycyanation of alkenes

Yuehua Zeng; Yajun Li; Daqi Lv; Hongli Bao

doi:10.1039/D0QO01437K

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Copper-catalyzed three-component oxycyanation of alkenes†

Yuehua Zeng,^a Yajun Li,

^a Daqi Lv^a and Hongli Bao

*^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, P. R. China
E-mail: hlbao@fjirsm.ac.cn

^b University of Chinese Academy of Sciences, Beijing, P. R. China

Abstract

A copper-catalyzed, three-component reaction for the direct oxycyanation of various alkenes with aryl diacyl peroxides and trimethylsilyl cyanide has been developed. Both unactivated alkenes and styrenes are reliable substrates and produce β-cyanohydrin derivatives. An asymmetric version of this reaction has been conducted and proceeds well.

This article is part of the themed collection: FOCUS: Radical-involved chemical transformations

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/D0QO01437K
Article type: Research Article
Submitted: 18 Nov 2020
Accepted: 22 Dec 2020
First published: 25 Dec 2020

Download Citation

Org. Chem. Front., 2021,8, 908-914

Permissions

Request permissions

Copper-catalyzed three-component oxycyanation of alkenes

Y. Zeng, Y. Li, D. Lv and H. Bao, Org. Chem. Front., 2021, 8, 908 DOI: 10.1039/D0QO01437K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic Chemistry Frontiers

Copper-catalyzed three-component oxycyanation of alkenes†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Copper-catalyzed three-component oxycyanation of alkenes

Social activity

Search articles by author

Spotlight

Advertisements