Recent advances in the synthesis of xanthones and azaxanthones
Diana I. S. P.
Resende, 
†ab
Fernando
Durães,
†ab
Miguel
Maia,
†ab
Emília
Sousa
*ab
and
Madalena M. M.
Pinto
ab
†ab
Fernando
Durães,
†ab
Miguel
Maia,
†ab
Emília
Sousa
*ab
and
Madalena M. M.
Pinto
ab
Abstract
Xanthones are important O-heteroaromatic tricyclic molecules exhibiting a wide range of bioactivities and can represent a showcase to highlight the recent techniques and strategies in organic synthesis towards lead discovery and optimization. This review gives an insight into the recent literature disclosed to obtain the xanthone core, including the drug-like azaxanthones, isosteres of xanthones, by exploiting the optimization of well-known procedures as well as disruptive developed methodologies. With this review, it is expected to provide a useful chemical toolbox to synthetic medicinal chemistry focusing on these privileged structures, covering from 2012 to 2020, with some older examples of azaxanthones.
- This article is part of the themed collection: 2020 Organic Chemistry Frontiers Review-type Articles
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